Abstract
Specific behavioral patterns are expressed by complex combinations of muscle coordination. Tremors are simple behavioral patterns and are the focus of studies investigating motor coordination mechanisms in the brain. T-type Ca2+ channels mediate intrinsic neuronal oscillations and rhythmic burst spiking, and facilitate the generation of tremor rhythms in motor circuits. Despite substantial evidence that T-type Ca2+ channels mediate pathological tremors, their roles in physiological motor coordination and behavior remain unknown. Here, we review recent progress in understanding the roles that T-type Ca2+ channels play under pathological conditions, and discuss the potential relevance of these channels in mediating physiological motor coordination.
Highlights
NEURAL CIRCUITSReviewed by: Michael Nitabach, Yale University School of Medicine, USA Chris I
Unraveling the mechanisms that underlie specific motor patterns is a challenging issue in neuroscience
Tremor-related rhythmic low-threshold spikes (LTS) is observed in VL thalamic neurons (Zirh et al, 1998; Magnin et al, 2000; Pifl et al, 2012). These results suggest that CaV3.1 expressing in VL thalamus (Figure 1) could be involved in the tremor generation
Summary
Reviewed by: Michael Nitabach, Yale University School of Medicine, USA Chris I. Specific behavioral patterns are expressed by complex combinations of muscle coordination. Tremors are simple behavioral patterns and are the focus of studies investigating motor coordination mechanisms in the brain. T-type Ca2+ channels mediate intrinsic neuronal oscillations and rhythmic burst spiking, and facilitate the generation of tremor rhythms in motor circuits. Despite substantial evidence that T-type Ca2+ channels mediate pathological tremors, their roles in physiological motor coordination and behavior remain unknown. We review recent progress in understanding the roles that T-type Ca2+ channels play under pathological conditions, and discuss the potential relevance of these channels in mediating physiological motor coordination
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