Abstract
The elderly are more prone to mortality from COVID-19 infection, as they are susceptible to develop acute respiratory distress syndrome (ARDS). For COVID-19 patients with ARDS caused by sepsis or septic shock, high-dose parenteral vitamin B12 appears to be a potential new treatment option. Vitamin B12 may play a substantial impact in COVID-19 morbidity and mortality reduction owing to its function in DNA synthesis, cellular control, improvement of anti-inflammatory immune responses, and decrease of pro-inflammatory responses. This review aims to assess the functional role of Vitamin B12 in COVID-19 in terms of its immunomodulatory effect, role in cellular and humoral immunity and maintaining the gut microbe homeostasis. From data inception to June 2021, accessible electronic databases were searched for research/review articles reporting on the function of Vitamin B12 in COVID-19. Scopus, Web of Science, PubMed, WHO worldwide research on COVID-19 and the clinical trials registration “https://clinicaltrials.gov/” were used to conduct the systematic search by using keywords: “COVID-19 and “Vitamin B12”. Also, based on these outcomes, it can be concluded that Vitamin B12 may have a potential role in preventing COVID-19 complications. Further, studies evaluating the role of Vitamin B12 in COVID-19 may open a new array of ideas on the optimal and the well-tolerated dose and timing of its administration in COVID-19 patients.
Highlights
This review aims to assess the functional role of Vitamin B12 in COVID-19 in terms of its immunomodulatory effect, role in cellular and humoral immunity and maintaining the gut microbe homeostasis
From data inception to June 2021, accessible electronic databases were searched for research/review articles reporting on the function of Vitamin B12 in COVID-19
SARS-CoV-2 is a virus with a positivesense single-stranded RNA genome that is the causative agent of COVID -19, which was initially detected in Wuhan, China in 2019 and has since caused countless deaths and economic losses all over the world.[1]
Summary
SARS-CoV-2 is a virus with a positivesense single-stranded RNA genome that is the causative agent of COVID -19, which was initially detected in Wuhan, China in 2019 and has since caused countless deaths and economic losses all over the world.[1] As of August 2021, the number of active cases of COVID-19 in India was 1.21%2 showing a significant increase in the number of new cases in many states of India, raising the possibility of a third wave of COVID-19, following the end of a devastating second wave of COVID-19. The presently available SARS CoV-2 vaccine offers some protection against new versions. COVID-19, needs a continual concern due to mutations, the possibility
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