Abstract
The Dipeptidyl peptidase-4 (DPP-4) activity influences metabolic, behavioral and intestinal disorders through the cleavage of key hormones and peptides. Some studies describe the existence of human DPP-4 homologs in commensal bacteria, for instance in Prevotella or Lactobacillus. However, the role of the gut microbiota as a source of DPP-4-like activity has never been investigated. Through the comparison of the DPP-4 activity in the cecal content of germ-free mice (GFM) and gnotobiotic mice colonized with the gut microbiota of a healthy subject, we bring the proof of concept that a significant DPP-4-like activity occurs in the microbiota. By analyzing the existing literature, we propose that DPP-4-like activity encoded by the intestinal microbiome could constitute a novel mechanism to modulate protein digestion as well as host metabolism and behavior.
Highlights
Marta Olivares 1, Valentina Schüppel 2,3, Ahmed M
Through the comparison of the Dipeptidyl peptidase-4 (DPP-4) activity in the cecal content of germ-free mice (GFM) and gnotobiotic mice colonized with the gut microbiota of a healthy subject, we bring the proof of concept that a significant DPP-4-like activity occurs in the microbiota
One study has tackled this issue when describing that the DPP-4 activity of the fungus Blastomyces dermatitidis, an opportunistic pathogen that can colonize the Abbreviations: DPP-4, Dipeptidyl peptidase-4; GFM, germ-free mice; GLP, Glucagon-like peptide; gastric inhibitory polypeptide (GIP), Gastric inhibitory polypeptide; KO, Knockout; peptide YY (PYY), Peptide YY; neuropeptide Y (NPY), Neuropeptide Y
Summary
Marta Olivares 1, Valentina Schüppel 2,3, Ahmed M. (2018) The Potential Role of the Dipeptidyl Peptidase-4-Like Activity From the Gut Microbiota on the Host THE GUT MICROBIOTA EXHIBITS DPP-4-LIKE ACTIVITY THAT COULD BE IMPLICATED IN HUMAN HEALTH
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