Abstract
ObjectiveIn our focus regarding microRNA, single‐stranded, small non‐coding RNAs, we aim to understand miRNA's roll and functional importance concerning congestive heart failure (CHF) and myxomatous mitral valve degeneration (MMVD). Characterizing expression profiles of circulating microRNAs via genome‐wide sequencing for dogs with CHF secondary to MMVD.Animals8 healthy client‐owned dogs and 8 middle age‐matched client‐owned dogs with CHF secondary to MMVD.ProceduresBlood samples were collected before administering cardiac medications for the management of CHF. Quantitative reverse transcription PCR (qRT‐PCR) assays were used to validate expression profiles of differentially expressed circulating microRNAs identified from NGS analysis of dogs with CHF.Conclusion and Clinical RelevanceAwaiting data indicating the patterns of microRNA expression are distinctive and denote molecular biomarkers with CHF in dogs with MMV.
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