The Potential Role of Kecombrang (Etlingera Elatior) Extract in Wound Management: A Review on its Anti-Oxidative, Anti-Inflammatory, Antimicrobial, and Anti-Melanogenesis Effects

Abstract

Wound healing is a complex process critical for tissue repair post-injury. Botanicals, renowned in traditional medicine, hold potential in wound healing due to their bioactive compounds. Etlingera elatior, a Zingiberaceae family member, is attracting attention for its diverse medicinal properties. Indigenous to Southeast Asia, it has been traditionally used for wound care, attributed to its anti-inflammatory, antioxidant, and antimicrobial effects. Recent scientific investigations highlight its ability to promote tissue repair, diminish inflammation, and counteract oxidative stress. These findings position Etlingera elatior as a promising candidate for wound healing management, particularly in plastic surgery. However, its clinical translation faces challenges, including limited clinical trials and mechanistic understanding, necessitating standardized extraction methods and regulatory approval. Bridging the gap between botanical therapies and clinical use requires robust clinical trials, mechanistic studies, and formulation optimization. Collaboration among researchers, clinicians, and regulators is pivotal in realizing Etlingera elatior's wound healing potential.