Abstract
The outbreak of novel coronavirus disease 2019 (COVID-19) in the city of Wuhan, Hubei Province, China, was declared a pandemic by the World Health Organization (WHO) on March 21, 2020. As of June 16, 2020, the World Health Organization (WHO) has reported near eight million cases and half a million deaths worldwide. The majority of cases have spontaneously resolved. However, some have developed various fatal complications including organ failure, septic shock, pulmonary edema, severe pneumonia, and Acute Respiratory Distress Syndrome (ARDS).
Highlights
Given the lack of effective antiviral therapy against COVID-19, current treatments mainly focus on symptomatic and respiratory support
Given its relatively low cost, readerly availability and acceptable safety profile, nitric oxide may be a game changer in COVID-19 management. We have found both clinical and preclinical evidence to support the beneficial role of Nitric Oxide (NO), possibly derived from its viricidal effect, on the coronavirus-mediated acute respiratory syndrome and the associated microthrombotic phenomenon
Acute Respiratory Distress Syndrome (ARDS) has been described in approximately 40% patients with 2019‐nCoV pneumonia [4], and it was crucial in increasing the risk of death
Summary
Given the lack of effective antiviral therapy against COVID-19, current treatments mainly focus on symptomatic and respiratory support. We have found both clinical and preclinical evidence to support the beneficial role of NO, possibly derived from its viricidal effect, on the coronavirus-mediated acute respiratory syndrome and the associated microthrombotic phenomenon.
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