The Potential Role of circRNAs Action on Classic Pathways of Signal Transduction PI3K/AKT in Treatment of Pancreatic Cancer

Abstract

Cancer is a highly complex disease characterized by diverse clinical manifestations and intricate etiology, involving DNA impairment, RNA dysregulation, protein dysfunction, and other contributing factors. The progression, invasion, angiogenesis, and metastasis of cancer are regulated by a multitude of pathways and agents that influence crucial cellular processes like apoptosis, cell survival, and gene expression. Among these pathways, the PI3K/AKT signaling pathway has emerged as a pivotal player, interacting with various intracellular agents including proteins, microRNAs (miRNAs), and circular RNAs (circRNAs). CircRNAs, in particular, form intricate networks that play essential roles in tumor development, transforming previous perspectives on cancer incidence, growth, metastasis, as well as diagnosis, prognosis, and treatment. A deeper understanding of these intricate intracellular interactions holds the potential for improved cancer control. In this comprehensive review, we explore the dynamic crosstalk between the PI3K/AKT signaling pathway, tumor initiation, and circRNAs. We delve into the intricate mechanisms through which circRNAs modulate cancer progression, invasion, and metastasis, shedding light on their multifaceted roles in shaping the cancer landscape. Furthermore, we discuss the potential of circRNAs as promising therapeutic targets and diagnostic biomarkers for cancer management. By elucidating the complex interplay between PI3K/AKT signaling, tumor biology, and circRNAs, we pave the way for the development of innovative therapeutic strategies in cancer treatment. This review underscores the importance of unraveling the intricate molecular networks governing cancer pathogenesis. By elucidating the involvement of the PI3K/AKT pathway and its intricate interplay with circRNAs, we contribute to a deeper understanding of the molecular underpinnings of cancer. Ultimately, this knowledge can guide the development of novel therapeutic interventions and diagnostic approaches for improved cancer management. As we gain a more comprehensive understanding of the complex interplay between the PI3K/AKT signaling pathway, tumor initiation, and circRNAs, we unlock the potential to revolutionize cancer treatment and pave the way for more personalized and effective therapeutic strategies.