Abstract
The most prominent pathological changes in patients with low back pain include Modic changes and degeneration of intervertebral discs. Presence of Cutibacterium acnes (C. acnes) and formation of biofilms have been linked to endplate changes and disc degeneration [ 1 Dudli S Liebenberg E Magnitsky S Miller S Demir-Deviren S Lotz JC. Propionibacterium acnes infected intervertebral discs cause vertebral bone marrow lesions consistent with Modic changes. J Orthop Res. 2016 Aug; 34: 1447-1455 Crossref PubMed Scopus (55) Google Scholar , 2 Georgy M Stern M Murphy K. What Is the Role of the Bacterium Propionibacterium acnes in Type 1 Modic Changes? A Review of the Literature. Can Assoc Radiol J. 2017 Nov; 68: 419-424 Crossref PubMed Scopus (13) Google Scholar , 3 Manniche C O'Neill S New insights link low-virulent disc infections to the etiology of severe disc degeneration and Modic changes. Future Sci OA. 2019 Mar 18; 5: FSO389 Crossref PubMed Scopus (10) Google Scholar , 4 Shan Z Zhang X Li S Yu T Liu J Zhao F. Propionibacterium acnes Incubation in the Discs Can Result in Time-Dependent Modic Changes: A Long-Term Rabbit Model. Spine (Phila Pa 1976). 2017 Nov 1; 42: 1595-1603 Crossref PubMed Scopus (14) Google Scholar ]. The aim of the current pilot was to test a minimally invasive model of disc degeneration and a potential of anti-bacterial biologic to reverse disc degeneration caused by C. acnes.
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