Abstract
Malignant Mesothelioma (MM) is a tumor of the serous membranes linked to exposure to asbestos. A chronic inflammatory response orchestrated by mesothelial cells contributes to the development and progression of MM. The evidence that: (a) multiple signaling pathways are aberrantly activated in MM cells; (b) asbestos mediated-chronic inflammation has a key role in MM carcinogenesis; (c) the deregulation of the immune system might favor the development of MM; and (d) a drug might have a better efficacy when injected into a serous cavity thus bypassing biotransformation and reaching an effective dose has prompted investigations to evaluate the effects of polyphenols for the therapy and prevention of MM. Dietary polyphenols are able to inhibit cancer cell growth by targeting multiple signaling pathways, reducing inflammation, and modulating immune response. The ability of polyphenols to modulate the production of pro-inflammatory molecules by targeting signaling pathways or ROS might represent a key mechanism to prevent and/or to contrast the development of MM. In this review, we will report the current knowledge on the ability of polyphenols to modulate the immune system and production of mediators of inflammation, thus revealing an important tool in preventing and/or counteracting the growth of MM.
Highlights
Malignant Mesothelioma (MM) is a rare primary tumor arising from the mesothelial cell linings of the serous membranes, most commonly involving the pleural and peritoneal spaces [1]
The evidence that: (a) multiple signaling pathways are aberrantly activated in MM cells [10]; (b) asbestos-mediated chronic inflammation through the release of reactive oxygen species (ROS), nitrogen species (RNS) and cytokines has a key role in MM carcinogenesis [11]; (c) the deregulation of the immune system might favor the onset of MM [9]; and (d) a drug might have a better efficacy when injected into a serous cavity, bypassing biotransformation and reaching an effective dose [12], have prompted investigations to evaluate the effects of polyphenols for the therapy and prevention of MM
The local or systemic administration of polyphenols might reduce the production of pro-inflammatory molecules by targeting signal transduction pathways or ROS and RNS
Summary
Malignant Mesothelioma (MM) is a rare primary tumor arising from the mesothelial cell linings of the serous membranes, most commonly involving the pleural and peritoneal spaces [1]. Taking into account the poor outcome and toxicity of chemotherapy, novel approaches based on targeting abnormally activated signaling pathways in MM cells were employed to improve survival in MM patients, as described in the review by Remon et al [5]. Dietary polyphenols possess pleiotropic properties capable of being able to (a) inhibit cancer cell growth by targeting multiple signaling pathways; (b) reduce inflammation and (c) modulate immune response [13,14,15,16,17]. The local or systemic administration of polyphenols might reduce the production of pro-inflammatory molecules by targeting signal transduction pathways or ROS and RNS. In this review we will report the current knowledge on the ability of polyphenols to modulate the immune system and production of mediators of inflammation in MM, revealing an important tool to prevent and/or to counteract the growth of MM
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
