Abstract

There are many extrinsic factors that can contribute to the premature aging of the skin. In recent years, the demand for natural cosmetic from the general population has noticeable grow. Therefore, this research aimed to investigate the bioproperties of sky fruit (Swietenia macrophylla) seed extract that could help to inhibit premature skin aging. Firstly, the extract and its fractions were tested on HaCaT cells for their wound healing properties. The presence of sky fruit’s extract and its fractions on scratch wound significantly improved cellular proliferation, migration, and closure of the wound. These effects were distinctly observed following the treatment with S. macrophylla hexane fraction (SMHF) and S. macrophylla water fraction (SMWF). Our continuous research study revealed that SMWF had antioxidant properties, which might be one of the factors contributing to its emerging wound healing properties because antioxidants are known to act as suppressors of the inflammatory pathway and aid the transition towards cell proliferation. In addition, all samples had critical wavelengths that indicated that they were able to absorb the whole UVB range and some parts of the UVA wavelength. This suggested that S. macrophylla might contain potential photoprotective bioactive compounds, which could be developed into anti-UVB photoprotective sunscreens. Thus, this warrants further studies focusing on isolation and identifications of the bioactive compounds responsible for both its photoprotective and wound healing properties. A deeper study on mechanisms of the pathways that were affected by these compounds should be conducted as well to better understand this natural product and develop it into a potential cosmeceutical ingredient.

Highlights

  • The term of cosmetics does cover items such as make-up and skincare products and daily personal hygienic consumables, such as soap, toothpaste, perfume, etc. [1]

  • The viability of the cells was measured using the MTT assay after the incubation period and the percentage of viable cells was calculated by normalizing against the non-treated control

  • We have shown that S. macrophylla extract and its fractions have wound healing properties on HaCaT cells, with S. macrophylla hexane fraction (SMHF) and S. macrophylla water fraction (SMWF) being some of the most effective ones among the fractions

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Summary

Introduction

The term of cosmetics does cover items such as make-up and skincare products and daily personal hygienic consumables, such as soap, toothpaste, perfume, etc. [1]. The term of cosmetics does cover items such as make-up and skincare products and daily personal hygienic consumables, such as soap, toothpaste, perfume, etc. It is unthinkable that we could live without cosmetics. The term cosmeceuticals came into play in the cosmetic industry in 1984, when it was coined by Albert Kligman. It means the combination of both “cosmetics” and “pharmaceuticals” and defines products that have both cosmetic and therapeutic properties [2]. Various grooming products fall into the category of cosmetics, there had been a continuous growth in consumer trends towards skincare cosmetics. It could be seen that the market itself is no longer contained towards women but had expanded towards men as well as; many are drawn towards the benefits of skincare cosmetics in boosting their appearance and confidence [3]

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