The potential of modern statistical analysis for the study of microcirculation parameters on the example of the bulbar conjunctiva biomicroscopy (lecture)

Abstract

The article is devoted to the correct use of modern statistical methods in data analysis. Considering the complexity of choosing and implementation of statistical method for data analysis and correct interpretation of the results we emphasize the importance of interaction between a medical scientist (biologist) and biostatistician. The article in a clear way emphasizes the correctpresentation of the results as a table and graphic form, recalls the differences between normal and other types of distribution of quantitative characteristics in the aggregate. Examples of using the multivariate methods are given in detail: discriminant analysis and logistic regression. The results of the original bulbar conjunctiva microcirculation study by the biomicroscopy were provided an example of the potential of these complex and infrequently used statistical methods. The conclusions emphasize the need for cooperation between a medical researcher (biologist) and biomedical statistician for the correct application of statistical methods, the maximum extraction of useful information from the primary data, as well as assistance in interpreting the results obtained. The authors provide an extensive list of statistical literature that studying can help medical scientists understand this complex science.