Abstract
Background Angiogenin (ANG) is a multifunctional angiogenic protein that participates in both normal development and diseases. Abnormal serum ANG levels are commonly reported in various diseases. However, whether ANG can serve as a diagnostic or prognostic marker for different diseases remains a matter of debate. Methods Here, we performed a systematic review and meta-analysis of the literature utilizing PubMed, Web of Science, and Scopus search engines to identify all publications comparing plasma or serum ANG levels between patients with different diseases and healthy controls, as were studies evaluating circulating ANG levels in healthy populations, pregnant women, or other demographic populations. Results This study demonstrated that the serum ANG concentration in healthy populations was 336.14 ± 142.83 ng/ml and remained relatively stable in different populations and regions. We noted no significant differences in serum ANG levels between patients and healthy controls, except in cases in which patients suffered from cancer or cardiovascular diseases. The serum ANG concentrations were significantly higher in patients who developed colorectal cancer, acute myeloid leukemia, multiple myeloma, myelodysplastic syndromes, and heart failure than those in healthy controls. Conclusion ANG has the potential of being a serum biomarker for cancers and cardiovascular diseases.
Highlights
Angiogenin (ANG), the fifth member of the vertebratespecific secreted ribonuclease A superfamily, is a multifunctional proangiogenic protein comprising a signal peptide whose cleavage facilitates its secretion
38 studies lacked a healthy control group, 18 studies lacked sufficient data for analysis, 16 studies reported incorrect data pertaining to serum ANG levels, and 5 studies used the same population
We found that 5 studies were eligible for inclusion in the analysis (Supplementary Table 1) and that serum ANG levels were not significantly different between patients with neurodegenerative diseases and healthy controls (Figure S3)
Summary
Angiogenin (ANG), the fifth member of the vertebratespecific secreted ribonuclease A superfamily, is a multifunctional proangiogenic protein comprising a signal peptide whose cleavage facilitates its secretion. Angiogenin (ANG) is a multifunctional angiogenic protein that participates in both normal development and diseases. Abnormal serum ANG levels are commonly reported in various diseases. Whether ANG can serve as a diagnostic or prognostic marker for different diseases remains a matter of debate. This study demonstrated that the serum ANG concentration in healthy populations was 336.14 ± 142.83 ng/ml and remained relatively stable in different populations and regions. We noted no significant differences in serum ANG levels between patients and healthy controls, except in cases in which patients suffered from cancer or cardiovascular diseases. The serum ANG concentrations were significantly higher in patients who developed colorectal cancer, acute myeloid leukemia, multiple myeloma, myelodysplastic syndromes, and heart failure than those in healthy controls. ANG has the potential of being a serum biomarker for cancers and cardiovascular diseases
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