Abstract
Hair loss or alopecia is a common dermatological issue that can affect millions of human population of all ages and both gender, male and female. Frequently, alopecia has been found to be associated with significant adverse effects or reduction of psychological and self-esteem. Consequently, this may lead to psychological problems such as depression and anxiety, thus it may negatively impact the quality of life as well. There are several types of hair loss including androgenetic alopecia (AGA), alopecia areata (AA), alopecia totalis (AT), Alopecia Universalis (AU), cicatricial alopecia (CA), senescent alopecia (SA), traction alopecia (TA) and telogen effluvium. However, this review will focus on the androgenic alopecia only. Androgenic alopecia (AGA) also known as male pattern baldness is referred to as hair loss that often occurs in men after puberty caused by the androgen. In addition, this review will discuss on the hair growth cycles and their mechanism on the androgenic alopecia and lastly the management of androgenic alopecia using plant derivatives and methods used in order to prolong the efficacy of androgenetic alopecia treatment.
Highlights
The human may have between 90,000 and 150,000 of hairs on their head and loss between 50 and 100 per day (Erdoğan, 2017; Sengar et al, 2018)
A study conducted in a group of patient with mild to moderate androgenic alopecia were treated with saw palmetto for 24 months and the result showed improvement in hair growth compared to a group of patients that treated with finasteride (Rossi et al, 2012)
Most of the plant derivatives or extract used in treating androgenic alopecia are targeting the inhibition of the 5α-reductase enzyme
Summary
The human may have between 90,000 and 150,000 of hairs on their head and loss between 50 and 100 per day (Erdoğan, 2017; Sengar et al, 2018). If the hair growth cycle was interrupted or the hair loss is more than 100 per day, hair loss disorder that associated with pathological issues is seen (Shaikh et al, 2016). It is important to understand the causes of hair loss thoroughly as it can be the key part of the treatment or prevention of the alopecia. In this review, the focus will be on the androgenic alopecia. This review will discuss the anatomy and physiology of hair and it’s growth cycle, causes of androgenic alopecia, and treatment and management of hair loss using plant derivatives. This review will discuss on the application of nanoparticles as one of the delivery systems potentially used for androgenic alopecia treatment
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