Abstract
Sterols play a unique role for the structural and dynamical organization of membranes. The current study reports data on the membrane properties of the phytosterol (3β,5α,22E)-stigmasta-7,22-dien-3-β-ol (α-spinasterol), which represents an important component of argan oil and have not been investigated so far in molecular detail. In particular, the impact of α-spinasterol on the structure and organization of lipid membranes was investigated and compared with those of cholesterol. Various membrane parameters such as the molecular packing of the phospholipid fatty acyl chains, the membrane permeability toward polar molecules, and the formation of lateral membrane domains were studied. The experiments were performed on lipid vesicles using methods of NMR spectroscopy and fluorescence spectroscopy and microscopy. The results show that α-spinasterol resembles the membrane behavior of cholesterol to some degree.
Highlights
The structural organization of cellular membranes is determined by a number of physico-chemical interactions between the individual membrane components, which allow membranes to realize the unique functions they play in complex cellular homeostasis
Α-Spinasterol, which is found in argan oil and in seed oil, is a component of natural food ingredients. e.g., argan oil is used as a traditional food ingredient in the ‘Amazigh diet’ and provides about 25% of the total diet fat intake to the indigenous consumers [9]
To investigate the effect(POPC-d of α-spinasterol on lipidLipid chain packing and its capability to induce of cholesterol with saturated lipid chains thatchain leads deuterated to an increase in phospholipid chain lipid interaction condensation, static 2 H-NMR
Summary
The structural organization of cellular membranes is determined by a number of physico-chemical interactions between the individual membrane components, which allow membranes to realize the unique functions they play in complex cellular homeostasis. Cholesterol is the molecule playing the decisive role for bringing about these specific membrane properties, in fungi and plants, other sterols such as ergosterol, campesterol, sitosterol, stigmasterol, and (3β,5α,22E)-stigmasta-7,22-dien-3-β-ol (α-spinasterol) take over the role of cholesterol. These sterols, which are structurally somewhat similar to cholesterol, have received special attention because of their putatively positive impact on human health. In searching for the components its reducing capacity for theeffects, plasmaα-spinasterol
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