Abstract
ObjectiveTo investigate the potential involvements of E-cadherin and β-catenin in meningioma.MethodsImmunohistochemistry staining was performed on samples from patients with meningioma. The results were graded according to the positive ratio and intensity of tissue immunoreactivity. The expression of E-cadherin and β-catenin in meningioma was analyzed by its relationship with WHO2007 grading, invasion, peritumoral edema and postoperative recurrence.ResultsThe positive rates of E-cadherin in meningioma WHO I, II, III were 92.69%, 33.33% and 0, respectively, (P<0.05); while the positive rates of β-catenin in meningioma WHO I, II, III were 82.93%, 33.33% and 20.00%, respectively, (P<0.05). The positive rate of E-cadherin in meningioma without invasion (94.12%) was higher than that with invasion (46.67%) (P<0.05). The difference in the positive rate of β-catenin between meningioma without invasion (88.24%) and meningioma with invasion (33.33%, P<0.05) was also statically significant. The positive rates of E-cadherin in meningioma with peritumoral edema 0, 1, 2, 3 were 93.75%, 85.71%, 60.00% and 0 respectively, (P<0.05); the positive rates of β-catenin in meningioma with peritumoral edema 0, 1, 2, 3 were 87.50%, 85.71%, 30.00% and 0 respectively, (P<0.01). The positive rates of E- cadherin in meningioma with postoperative recurrence were 33.33%, and the positive rate with postoperative non-recurrence was 90.00% (P<0.01). The positive rates of β-catenin in meningioma with postoperative recurrence and non-recurrence were 11.11%, 85.00%, respectively (P<0.01).ConclusionThe expression levels of E- cadherin and β-catenin correlated closely to the WHO 2007 grading criteria for meningioma. In atypical or malignant meningioma, the expression levels of E-cadherin and β-catenin were significantly lower. The expression levels of E- cadherin and β-catenin were also closely correlated with the invasion status of meningioma, the size of the peritumoral edema and the recurrent probabilities of the meningioma, all in an inverse correlationship. Taken together, the present study provided novel molecular targets in clinical treatments to meningioma.
Highlights
Meningioma originates from the derivatives of meninges and arachnoid cap cells
We found that the positive rates of E-cadherin were 93.75%
We investigated the expression levels of E-cadherin and bcatenin among different types of meningioma
Summary
Meningioma originates from the derivatives of meninges and arachnoid cap cells. Its incidence as primary intracranial tumors is very high (15–20%), ranked just behind the cerebral glioma [1,2].The biological characteristics of meningioma are diverse. Meningioma originates from the derivatives of meninges and arachnoid cap cells. Its incidence as primary intracranial tumors is very high (15–20%), ranked just behind the cerebral glioma [1,2]. The biological characteristics of meningioma are diverse. Most of tumors show retarded growth, but a small portion display invasive growth. Most meningiomas can be cured by complete surgical removal, there are always the risks of recurrence. The present theory on the occurrence and the development of meningiomas include polygenetic and multiple molecular factors [3,4]. Recent studies suggested that E-cadherinmediated cell-cell adhesion is critical in these processes [5,6]. The objectives of this study were to investigate the expression levels of
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