Abstract
Background: Infertility has been more common problems among couple of reproductive age. One of the factors causing this disorder is unhealthy environmental factors including exposure to cigarette smoke. Polynuclear aromatic hydrocarbons (PAHs) in cigarette smoke can cause testicular atrophy, while the free radicals can inhibit the stages of spermatogenesis, and nicotine in cigarettes affects the brain dopamine levels affecting the levels of GnRH, and subsequently affect the levels of FSH and LH needed in spermatogenesis. The use of Mucuna pruriens seed extract containing antioxidants and L-dopa is expected to improve the quality of sperm after exposure to cigarette smoke.
 Objective: This study aimed to determine the effect of Mucuna pruriens seed extract on the sperm quality in mice exposed to cigarette smoke.
 Methods: This study was an experimental study with a post test only control group design. A total of 20 mice were divided into 4 groups of five mice each. All groups were exposed to cigarette smoke. Group 1 was the negative control exposed to cigarette smoke. Groups 2, 3, 4 were exposed to cigarettes smoke and given Mucuna pruriens seed extracts at the dose of 250; 300; and 350 mg/Kg BW/day. Parameters of sperm quality included concentration, morphology, motility and viability.
 Results: Post hoc tests showed there were significant differences among treatment groups.
 Conclusion: the administration of Mucuna pruriens seed extract affects the sperm quality of BALB/c mice exposed to cigarettes smoke.
 Bangladesh Journal of Medical Science Vol.20(4) 2021 p.768-773
Highlights
About 12-15% of couples of reproductive age have problems to conceive and produce offspring 1in which 20-40% are due to male factors
Free radicals in cigarette smoke may cause oxidative stress in the male reproductive system, disrupting spermatogenesis, the nicotine reduce brain dopamine levels leading to reduced brain Gonadotropin-releasing hormone (GnRH) levels required in the secretion of LH and FSH hormones needed in the process of sperm production, and Polynuclear Aromatic Hydrogen (PAH) can
Based on sperm quality parameters, including viability, concentration, morphology and motility, it can be concluded that Mucuna pruriens seed extract affects the quality of sperm in Balb/C mice exposed to cigarettes smoke
Summary
About 12-15% of couples of reproductive age have problems to conceive and produce offspring 1in which 20-40% are due to male factors. Free radicals in cigarette smoke may cause oxidative stress in the male reproductive system, disrupting spermatogenesis, the nicotine reduce brain dopamine levels leading to reduced brain Gonadotropin-releasing hormone (GnRH) levels required in the secretion of LH and FSH hormones needed in the process of sperm production, and Polynuclear Aromatic Hydrogen (PAH) can. The use of Mucuna pruriens seed extract containing antioxidants and L-dopa is expected to improve the quality of sperm after exposure to cigarette smoke. Objective: This study aimed to determine the effect of Mucuna pruriens seed extract on the sperm quality in mice exposed to cigarette smoke. Groups 2, 3, 4 were exposed to cigarettes smoke and given Mucuna pruriens seed extracts at the dose of 250; 300; and 350 mg/Kg BW/day. Conclusion: the administration of Mucuna pruriens seed extract affects the sperm quality of BALB/c mice exposed to cigarettes smoke
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