The potential diagnostic value of immunohistochemical expression of trop2 in papillary thyroid carcinoma

Abstract

Abstract Background The diagnosis of the papillary thyroid carcinoma depends upon the characteristic histopathological features, however there may be borderline cases with controversial features necessitating the use of immunohistochemical studies.Trophoblastic cell surface antigen 2 (TROP-2) is a promising marker that is used recently in the diagnosis of PTC. Aim of the Work To highlight the diagnostic value of TROP-2 marker in PTC in comparison with other benign and borderline thyroid lesions on tissue specimens. Materials and Methods This retrospective cohort study included 55 cases of PTC, its histopathological variants, benign and borderline thyroid lesions received at pathology department, Faculty of medicine, Ain Shams university between 2011 and 2016. Immunohistochemical evaluation of TROP-2 was applied on. Membranous staining without cytoplasm in > 5% of cells was considered positive. TROP-2 expression in various thyroid lesions were determined by immunohistochemical staining and results were statistically analyzed. Results Among the studied cases, 85.1% of PTC demonstrated TROP-2 staining. Most of the cases revealed diffuse staining. No significant staining difference was reported between studied classic and non classic variants. TROP-2 sensitivity and specificity were 85.1% and 94.4%. Conclusion In view of present study we concluded the use of TROP-2 as a novel promising marker in the diagnosis of PTC as its positivity was significantly higher in PTC compared to all other non PTC lesion .