Abstract
Panax ginseng (P. ginseng) has been widely used for many traditional medicinal therapies in Korea and Japan. Oral administration of P. ginseng-head BuOH fraction (PGHB) was found to be safe in acute toxicity (LD50>5,000mg/kg). PGHB inhibited the partially acetic acid-induced writhes (approximately 32%, P<0.05) in mice. This result indicates that PGHB possess antinociceptive activity in chemical-induced pain test models. PGHB (500mg/kg) strikingly inhibited acetic acid-induced extravasation of Evans blue dye in mice by approximately 20.6% (P<0.05), and similar to suppressive effect of ibuprofen (27.7%) as a positive control drug. Also, PGHB reduced approximately 4.55% of carrageenan-induced paw edema at 3h after oral administration. In CIA mice, PGHB suppressed the production of serum IL-6. This suggests that it is concluded that PGHB has potential analgesic and anti-inflammatory activities, and will be supporting the evidence for the potential anti-rheumatoid activity of Korean P. ginseng head.
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