Abstract
The study was conducted to screen the antipyretic activity of aqueous of extract of the leaves of sernai (Wedelia biflora) with split-plot design. Eighteen healthy mice weighing between (20-25 g), aged 2-3 months were divided into six groups of three animals each: negative control group were given distilled water (P0), P1, and P2 as a positive control respectively given salicylic acid 42.25 mg/kg body weight, the amino phenol 25 mg/kg body weight, group P3, P4, and P5 given of sernai leaf aqueous extract at a concentration of 50, 75, and 100% respectively. The initial rectal temperature of each animal was recorded by digital thermometer. The pyrexia was induced by injecting a solution of 12.5% peptone. The difference in temperature was observed every 30 minutes for 3 hours and respective time interval was found out by statistical method. The results showed that the water extract of leaves sernai with various concentrations significantly different (P0.01) with an observation time. Average temperatures in the P5 mice was significantly different (P0.05) with P0. P3 and P4 is not significantly different from P0, but P3 and P4 significantly different (P0.05) with P2 and not significantly different from P1. P5 was not significantly different from the P2 and P1 significantly different. It was concluded that the aqueous extract of leaves sernai potential as an antipyretic in mice and at concentrations of 50 and 75% effective in reducing fever in mice tend equivalent to the amino phenol, while the concentration of 100% with salicylic acid.Key words: amino fenol, antipyretic, salicylic acid, sernai
Highlights
The study was conducted to screen the antipyretic activity of aqueous of extract of the leaves of sernai (Wedelia biflora) with split-plot design
The results showed that the water extract of leaves sernai with various concentrations significantly different (P
Bagian Farmakologi Fakultas, Kedokteran Universitas Indonesia, Jakarta
Summary
Obat antipiretik hanya digunakan pada saat demam dan tidak boleh digunakan secara rutin karena bersifat toksik. Ekstrak sernai juga mampu mencegah reaksi alergi pada mencit yang diinduksi ovalbumin (Rinidar et al, 2005). Pada saat ini permintaan akan triterpen meningkat tajam, hal ini disebabkan kemampuannnya bertindak dalam menghambat PGE2 dan juga menghambat produksi nuclear factor-kB (NF-kB) (Salminen et al, 2008; Biswas et al, 2009), juga mampu menurunkan kolesterol. Sedikitnya saat ini ada 25 studi klinis, 20 hak paten, dan 10 produk berbasis triterpen komersil yang dijual di seluruh dunia dan diperkirakan ada 2400 subyek telah mengambil bagian dalam studi klinis dengan berbagai jenis triterpen dan dilaporkan bahwa bahwa pada dosis 25 g/hari dikonsumsi tidak menimbulkan efek samping (Moreau et al, 2002). Menindaklanjuti hal ini, maka perlu dikaji secara mendalam tentang potensi ekstrak air daun sernai terhadap efek antipiretik pada mencit dibandingkan dengan para amino fenol dan asam salisilat
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