The Potency of Ficus deltoidei Jack Bioactive as An Antidiabetic Treament: In Silico Study

Abstract

Introduction: Type 2 Diabetes Mellitus (T2DM) is a metabolic disease with an increasing prevalence. T2DM is related to chronic low-grade inflammation or meta-inflammation conditions. Nowadays, treatment begins to target the molecules or proteins involved in T2DM. Peroxisome Proliferator Activator Receptor gamma (PPAR-γ) is one of the proteins involved in T2DM. The herb, Ficus deltoidea Jack (Tabat Barito), is a potential solution to finding molecular medicine with bioactive compounds. Extract from Tabat Barito (Ficus deltoidea Jack) has proven to be an antidiabetic. Objective:This research aims to analyze the biological and pharmacological bioactive compounds of Ficus deltoidea Jack as an antidiabetic through molecular docking study. Methods:The bioactive compounds of Ficus deltoidea Jack were determined from the literature. PASS (Prediction of Activity Spectra for Substances) was used to analyze the bioactive compounds. SwissADME was used to know the pharmacology properties. Molecular docking was used to find the interaction between bioactive compounds and PPAR-γ. Results: Ficus deltoidea Jack has many bioactive compounds. Lupeol, Vitexin, and Isovitexin were chosen to advance analysis using PASS and SwissADME. All of them had antidiabetic activity. SwissADME was used to identify the pharmacology properties. The result showed that Vitexin has the strong ΔGibbs (- 6.59kcal/ and mol) and Inhibition constant (Ki) (14.77 μM) compare to other compounds. Conclusion: Ficus deltoidea Jack has the potency to be developed as an antidiabetic herbal through the activity of the Vitexin compound.