Abstract
The development of the Sertoli cells of the testis of the white mouse was studied with the electron microscope at weekly intervals from birth to sexual maturity, utilizing fixation in a glutaraldehyde-formaldehyde mixture followed by OsO4. The Sertoli cells underwent a rapid structural differentiation between 1–2 and 4–5 weeks postnatally. Large increases were noted in cell size, in the extent of cell processes extending between germinal cells, and in the abundance of certain cytoplasmic organelles, particularly the agranular endoplasmic reticulum and Golgi apparatus. The apparent sequences of development of the characteristic junctional complexes and tri-partite nucleoli of Sertoli cells were observed. The development of structural specializations is discussed in terms of established and proposed functions of the Sertoli cells, and the demonstration of abundant agranular endoplasmic reticulum is considered in relation to the possibility of steroid hormone production by Sertoli cells.
Published Version
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