Abstract
It was shown recently that skeletal and heart muscle mitochondria contain bound creatine kinase; the bound enzyme is different from the cytoplasmic one (Jacobs, Heldt and Klingenberg, 1964). Because this enzyme is able, in the presence of creatine, to regenerate ADP continuously as phosphate acceptor for the respiratory chain it might have a role in the control of mitochondrial respiration in response to the requirements of muscle contraction. This paper presents quantitative data on the role of bound creatine kinase in mitochondrial respiration and gives evidence that extra mitochondrial adenine nucleotides are required for the function of this acceptor system which does not act as an acceptor for intramitochondrial ATP.
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