Abstract
The possible difference in digitalis sensitivity between males and females was determined in three groups of young patients with rheumatic heart disease. A total of 183 patients with 306 separate admissions was studied. In the two groups of male patients receiving digitalis, 22.2 and 20.6 per cent developed digitalis-induced arrhythmias. In contrast, only 10.2 per cent of the female patients receiving digitalis became toxic. Although this difference is not highly significant statistically, it is quite suggestive that the female is less sensitive to the cardiotoxic effects of digitalis. This would be clinical confirmation of previously reported experimental work showing sex differences in digitalis sensitivity.
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