The Possible Radio Protective Role of Gum Arabic on The Kidney Cortex of Adult Male Albino Rats

Abstract

Aim of the work: the use of ionizing radiation exposure increases, oxidative stress especially for cancer patients. Therefore, there is a critical need to develop antioxidants that prevent oxidative stress damage. Gum Arabic is an antioxidant and anti-inflammatory mediator. This study aimed to assess the possible radio protective effect of gum Arabic (Acacia senegal) against gamma irradiation-induced injury on the rat kidney. Materials and Methods: four groups of male Albino rats (each of 12 rats) received normal saline (G1), dose 5Gy of gamma irradiation (G2), orally administered with 25 mg/kg gum Arabic for 3 weeks (G3) and gamma irradiation plus oral gum Arabic administration for 7 days before and 21 days after irradiation (G4). Results: in the gamma irradiated group, histopathological and ultrastructural examinations of the rat kidney cortical tissue revealed signs of degeneration to the cortical renal tubules and glomeruli. In contrast, gum Arabic treatment alleviated most of the damaging effects of gamma radiation. Conclusion: oral administration of gum Arabic could ameliorate adverse gamma radiation-induced effects that might be attributed to its antioxidative and free radical scavenging effects.