The Possible Protective Role of Sesame Oil on Skeletal Muscle Regeneration in Induced Red-Bull Injury: Experimental Study

Abstract

Background: Energy drinks (Eds), including Red Bull, were introduced to United States markets in 1997. Consumption hasincreased worldwide mainly consumed by athletes and teenagers as they are seeking for increase their energy level. Seasme oil(SO) has been known to have anti-inflammatory and antioxidant properties.Aim: The current study was designed to elucidate study the possible protective role of SO on skeletal muscle regeneration inRed Bull experimentally induced injury.Materials and Methods: Twenty adult albino rats were divided into four groups, control, sham control, RB and RB+SO.Skeletal muscle sections were subjected to histological, morphometric, biochemical and statistical studies.Results: RB induced various histological changes in skeletal muscle in the form of congestion, atypical fibre, multiple fibroblastand dark nuclei. RB also caused a sig increase in area % collagen, area % of caspase3 immunoexpression (IE), count of alphasmooth muscle actin IE(no I SMA) and count of +ve CD34 IE were recorded. Sig increase in the activity of interleukin-6(IL-6)and PI3K and AKT proteins. Concomitant administration with SO improved sig the previously mentioned changes.Conclusion: It can be concluded that SO enhanced skeletal muscle regeneration in RB induced muscle injury expressed as adefinite ameliorating effect to the induced inflammatory and degenerative changes.