Abstract
This study aims to know the therapeutic role of one of the types of plant flavonoids (rutin) in reducing the negative effects resulting from inhalation of formaldehyde 40% and its effect on lung function and tissues of rats. As well as clarifying the effective role of rutin in enhancing the effectiveness of antioxidants and reducing the oxidation process, as rutin acts as a natural antioxidant and can be found in many plant species. In this investigation, a total of twenty-four white male rats were used, and these rats were randomly assigned to four groups, with six rats in each group. The experiment was conducted over a period of three weeks and the first group served as a control, while the other groups (G1, G2, and G3) served as experimental groups. The results of evaluating some antioxidants (SOD, CAT, GSTs, and TAOC) and some oxidants (MDA, NO). revealed a clear imbalance between oxidants and antioxidants, increased oxidative stress, pathological changes in lung tissue such as enlargement and widening of the alveoli, and an increase in endothelial thickness. On the other hand, the rutin dosage increased antioxidants, decreased oxidative stress, and improved lung tissue to levels equivalent to the control group
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