The possible mechanisms of the high pressure-induced motor disturbances in the cat

Abstract

High pressures elicit a high-frequency tremor (8–12 c/sec) in mammals, the mechanisms of which are still unknown. The present study shows that: (1) in spite of many similarities observed between the EMG characteristics of harmaline-induced tremor and pressure-induced tremor, cerebellar lesions which suppress the harmaline-induced tremor, do not modify the characteristics of the pressure-induced tremor; (2) at depth, the caudal part of the spinal cat (section at T 9–T 10 spinal level) displays irregular spontaneous EMG activities which can be clonic or rhythmic (4–8 c/sec), and a neuromuscular stretch hyperreflexivity. These data suggest that the origin of the pressure-induced tremor is spinal and neuromuscular rather than cerebellar.