THE POSSIBLE EFFECTS OF POLYAMINES IN MULTIPLE SCLEROSIS PATIENTS ON NEW LESION DEVELOPMENT AND DISABILITY

Asli Bolayir,Hasan Kilicgun,Serkan Kapancik,Veysel Kenan Celik,Seyda Figul Gokce,Hasan Ata Bolayir

doi:10.29121/granthaalayah.v6.i6.2018.1401

Asli Bolayir, Hasan Kilicgun + Show 4 more

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https://doi.org/10.29121/granthaalayah.v6.i6.2018.1401

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Abstract

Background: Multiple sclerosis (MS) is a demyelinating autoimmune disease characterized by the infiltration of T cells into the central nervous system. Polyamines, which contribute to cell proliferation, hypertrophy and tissue development, have some tissue-specific roles in brain tissue. So, we aimed in this study to present the possible effects of polyamines on MS. Method: Thirty- five patients with MS and 35 sex and age-matched control were included in this study. Arginine decarboxylase (ADC), ornithine decarboxylase (ODC) and agmatinase levels were measured by ELISA kits. Results: The patient group had higher ODC and agmatinase levels than controls. The correlation analyses between ODC, ADC, and agmatinase levels and disease duration were revealed that there was a negligible positive relationship between disease duration and agmatinase, with negligible negative relationship between disease duration and ODC and ADC. Additionally, there were showed respectively moderate and weak positive correlations between EDSS (Expanded Disability Status Scale) scores and newly developed lesions and ODC and agmatinase levels. Conclusions: Elevated polyamine synthesis in MS patients was presented by detecting increased ODC, ADC and agmatinase levels compared to controls. Besides this increased polyamine synthesis in MS patients was also related with disease duration, number of newly developed lesions and disability.

Highlights

Multiple sclerosis (MS) is a demyelinating autoimmune disease characterized by the infiltration of T cells into the central nervous system (CNS) due to impaired blood brain barrier (BBB) [1]
It has been shown that administration of spermidine in experimental autoimmune encephalomyelitis disease in animal models may be beneficial for suppressing signs by reducing the reactive oxygen radicals responsible for the pathogenesis of MS [26]
The level of agmatinase increases, if it is considered that the ornithine decarboxylase (ODC) enzyme is the rate-limiting enzyme in the polyamine synthesis pathway, these results suggest that polyamine synthesis is reduced in the later stages of MS disease

Summary

Introduction

Multiple sclerosis (MS) is a demyelinating autoimmune disease characterized by the infiltration of T cells into the central nervous system (CNS) due to impaired blood brain barrier (BBB) [1]. Multiple sclerosis (MS) is a demyelinating autoimmune disease characterized by the infiltration of T cells into the central nervous system. There were showed respectively moderate and weak positive correlations between EDSS (Expanded Disability Status Scale) scores and newly developed lesions and ODC and agmatinase levels. Conclusions: Elevated polyamine synthesis in MS patients was presented by detecting increased ODC, ADC and agmatinase levels compared to controls. Besides this increased polyamine synthesis in MS patients was related with disease duration, number of newly developed lesions and disability

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