Abstract
Based on a comprehensive mathematical model of the energy and redox metabolism of human erythrocytes we calculated stationary metabolic states of the cell varying the activity of the participating enzymes by several orders of magnitude. To compare the computational results with clinical and experimental data reported for various enzymopathies of the red cell, the three essential metabolic variables ATP, GSH and osmolarity were included in a “homeostasis function” which allows us to estimate the range of enzyme activities in which the metabolic alterations should be either tolerable, associated with non-chronic or chronic hemolytic diseases, or letal.
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