Abstract
Antibodies (Ab), especially natural, display multiple specificity not only due to intrinsic conformational dynamics. With computational analysis the distribution of identical and homologous peptides has been studied in surface proteins from RNA and DNA viruses of widely distributed infections. It was established that each virus protein shared the fragments homologous to other virus proteins that allowed to propose the existence of the peptide continuum of the protein relationship (PCPR). Possible manifestations of PCPR are multiple reactivity and autoreactivity in Ab and therefore it is not possible to consider the immune methods of virus identification as high reliable because of crossing interactions. The PCPR excludes the existence of 100% specificity in immune tests for virus identification. Immunodiagnostic collisions may occur either in identification of virus itself or identification of Ab to viruses. Also PCPR may be responsible for heterologous immunity and consequently the infection associated with severe pathology. The comparative analysis of peptide relationship of H1N1 influenza virus nucleoprotein and human proteins found out, beyond early described its common motif with human hypocretin receptor 2, peptides homologous to those in melanotonin and glutamate receptors and three ion channels. It allows to propose that the sleep disorder narcolepsy associated with Pandemrix vaccination (an adjuvanted, influenza pandemic vaccine) and also with infection by influenza virus during the 2009 A(H1N1) influenza pandemic may be determined not only by Ab to the peptide motif common to influenza nucleoprotein and hypocretin receptor but also Ab to melanotonin and glutamate receptors and ion channels. Decreasing and even avoiding risks of complications from vaccination may be feasible by means of a computer analysis of vaccine proteins for the occurrence of epitopes homologous to the human protein those and particularly by an analysis of Ab profiles induced by vaccine using microarrays with the large number of human protein antigens.
Highlights
Инфекция и иммунитет the fragments homologous to other virus proteins that allowed to propose the existence of the peptide continuum of the protein relationship (PCPR)
Possible manifestations of PCPR are multiple reactivity and autoreactivity in Ab and it is not possible to consider the immune methods of virus identification as high reliable because of crossing interactions
PCPR may be responsible for heterologous immunity and the infection associated with severe pathology
Summary
Коллизии в иммунодиагностике и вакцинации анализа блочного родства белков (то есть ПКРБ) среди разных вирусов, которое может быть источником сложностей и ошибок при идентификации вирусов методами, основанными на использовании иммунологических принципов. Поскольку каждый из исследованных вирусных белков, как правило, содержал декапептиды, гомологичные таковым нескольких белков других вирусов, то это дает основание предполагать существование ПКРБ вирусов, которое можно было бы схематично представить в виде графа, узлами которого являются (точки на графе) сами вирусные белки.
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
