Abstract
The Possible Ameliorative Effect of Hesperidin Administration in Aluminum Phosphide Induced Acute Nephrotoxicity in Adult Albino Rats
Highlights
Acute renal injury is a major public health problem and is considered as a major cause of morbidity and mortality (Hayek et al, 2020)
Biochemical parameters results: The results revealed a significant increase in serum urea and creatinine level and a significant decrease in serum protein in Aluminum phosphide (ALP) treated group in comparison to both control and HSD-treated groups
Oxidative enzymes activity results: The results revealed a significant decrease in plasma glutathione Stransferase (GST) level and superoxide dismutase (SOD) activity in ALP-treated group in comparison to both control and HSD-treated groups
Summary
Acute renal injury is a major public health problem and is considered as a major cause of morbidity and mortality (Hayek et al, 2020). Hesperidin (HSD) is a flavanone glycoside which is found in citrus fruits and is considered as anti-inflammatory and antioxidant agent It can decrease oxidative stress and production of proinflammatory cytokines in mice (Afra et al, 2019). Aim of the work: The present study aimed to explore the probable ameliorative effect of antioxidant hesperidin on aluminum phosphide-induced nephrotoxic changes in adult albino rats after acute exposure. Results: The results revealed that HSD therapy provided marked improvement against ALP-induced acute renal toxicity which appeared in biochemical, histological and proximal convoluted tubules changes which were assessed by light and electron microscopes. Conclusion: The study concluded that HSD has an ameliorative effect in ALP induced-nephrotoxicity in adult albino rats. It increases the hope of using HSD as a new effective antidote in ALP-induced toxicity and gives an opportunity for experimental and clinical trials to evaluate its role in ALP toxicity management
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