The possibility of positive selection for both F18 +Escherichia coli and stress resistant pigs opens new perspectives for pig breeding

Abstract

F18 + Escherichia coli infections causing post-weaning diarrhoea and/or oedema disease are a major cause of economic losses in pig industry. To date, no preventive strategy can protect pigs from F18 + E. coli infections. One of the most attractive approaches to eliminate F18 + E. coli infections is the selection for pigs that are resistant to F18 + E. coli infections. However, this strategy was not believed to be favourable because of reports of genetic association with the stress-susceptibility gene in the Swiss Landrace. To investigate this potential association more thoroughly, 131 randomly selected Belgian hybrid pigs were genotyped for both the F18 + E. coli resistance alleles ( FUT1 A ) and the stress-susceptibility alleles ( RYR1 T ) and their association was investigated by determining the linkage disequilibrium. This linkage disequilibrium (LD = − 0.0149) is close to zero and does not differ significantly from 0 (likelihood ratio test χ 1 2 = 1.123 , P = 0.29), demonstrating no association between the FUT1 A and RYR1 T alleles. Furthermore, only a small fraction (4.6%) of the Belgian pigs was found to be resistant to F18 + E. coli infections. Our results suggest that selection for F18 + E. coli resistant pigs might be an attractive approach to prevent pigs from F18 + E. coli infections, unlike to what has previously been postulated.