The possibility of applying a monoclonal tumor-restricted antibody in cytologic diagnosis of lung cancer in serous effusions

Abstract

Fifty serous effusions resulting from a lung disease have been examined. A tumor-restricted anticarcinoma of the lung (rot a small cell lung carcinoma) MAb, termed HuTu-m3, has been used together with conventional cytology to examine the cells. The results achieved by immunocytochernical examination have been compared with cytologic results and the data obtained have been evaluated in terms of sensitivity, specificity, predictive value and test efficiency. The final analysis suggests that this technique might be helpful in the diagnosis of serous effusions by increasing the sensitivity of cancer cell cytologic detection.