The possibilities of serum cystamine C in diagnostic of pyelonephritis in pregnant women Hematology.

Abstract

The cystamine C is considered as one of markers of functional condition of pregnant women. The actual study was carried out to assess possibility of applying cystamine C as a biological marker of pyelonephritis in pregnant women. The sampling consisted of 126 pregnant women with various terms of gestation. The participants were separated in two groups. The group I included 64 women with pyelonephritis and the group II included 62 women without pyelonephritis. Te serum values of cystamine C were detected using enzyme-linked immunosorbent assay. The statistical analysis was implemented using non-parametric methods, including Kruskal-Wallis criterion for comparison of 3 independent groups and Mann-Whitney (Wilcoxon) criterion for a posteriori comparisons. The comparative analysis of values of cystamine C in pregnant women discovered, depending on term, increasing of its level since term II - 0.815 (0.622; 0.914) and even higher values in term III - 1.076 (0.917; 1.463) (p=0.0007). This trend repeats at minute analysis of indices of cystamine C in each group separately. The differences in values of cystamine C in two groups in total and between terms were lower statistically significant levels. However, in the group of women with pyelonephritis its values in terms I and III were higher than in the group of women without pyelonephritis. The highest values of content of cystamine C in pregnant women (p=0.0007) were observed in term III. The inter-group differences of serum values of content of cystamine C were absent that does not allow to recommend it as a early marker of damage of kidneys in pregnant women with pyelonephritis.