Abstract
To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. 60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio. This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03). Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.
Highlights
Tobacco exposureTobacco consumption is a global health problem; it is considered a pandemic involving 1.3 billion people
We examined the effect of botulinum toxin type A (BontA) in healthy rats, diabetic rats and, in rats exposed to smoke for 28-days, for the viability of skin flaps
BontA showed a difference in health and diabetic animals, there was no BontA effect in the flap viability for the tobacco-exposed group[9]
Summary
Tobacco exposureTobacco consumption is a global health problem; it is considered a pandemic involving 1.3 billion people. Tobacco-exposure increases three times the rate of complications in wound Healing when Compared to a health patient[2,3]. For this reason, several strategies were studied to decrease surgical complications[4-6], one of the strategies was to use BontA as a vasodilator[7-9]. BontA showed a difference in health and diabetic animals, there was no BontA effect in the flap viability for the tobacco-exposed group[9]. This hypothesis was based on other studies[10,11]. Considering our previous study and the controversial results In the literature, we decided to test the effect of BontA in random flap for different smoke exposure periods
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.