Abstract
To evaluate the effect of Botulinum Toxin A in different time of tobacco exposure. 60 male, Wistar rats were divided into two tobacco exposure groups: a 2- month or a 4-month regimen. After this period, these two groups were subdivided as two: saline solution(SS) or botulinum toxin A(Bonta), at the time of the surgery. Seven days before the SS or Bonta injection, the animals were submitted to a random flap (3x10cm). On the seventh postoperative day, all animals were assessed for total flap area, viable area, and the viable/ total area ratio. This study showed a difference between groups 2-month saline vs. BontA injection (p=0.04); groups 4-month saline vs. BontA injection (p=0.001); groups 2-month saline vs. 4-month BontA (p=0.003), and, between groups 2- month BontA vs. 4-month saline(p=0.03). Botulinum Toxin A increased random flap viability in tobacco-exposed rats. Two months of tobacco exposure had the same effect as exposure for four months.
Highlights
Tobacco exposureTobacco consumption is a global health problem; it is considered a pandemic involving 1.3 billion people
We examined the effect of botulinum toxin type A (BontA) in healthy rats, diabetic rats and, in rats exposed to smoke for 28-days, for the viability of skin flaps
BontA showed a difference in health and diabetic animals, there was no BontA effect in the flap viability for the tobacco-exposed group[9]
Summary
Tobacco exposureTobacco consumption is a global health problem; it is considered a pandemic involving 1.3 billion people. Tobacco-exposure increases three times the rate of complications in wound Healing when Compared to a health patient[2,3]. For this reason, several strategies were studied to decrease surgical complications[4-6], one of the strategies was to use BontA as a vasodilator[7-9]. BontA showed a difference in health and diabetic animals, there was no BontA effect in the flap viability for the tobacco-exposed group[9]. This hypothesis was based on other studies[10,11]. Considering our previous study and the controversial results In the literature, we decided to test the effect of BontA in random flap for different smoke exposure periods
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