Abstract
Methicillin-resistant Staphylococcus aureus (MRSA) have become antibiotic resistant by several mutations due to the random and widespread use of antibiotics for years. Since many strains can easily become resistant to many antibiotics, various treatment mechanisms against MRSA infections have begun to be developed. Various disinfectants, detergents, organic solvents and chemicals have been tried to create synergistic effects either by themselves or by combining them with innovative methods. In this study, photodynamic therapy on MRSA strains and adjuvant effect of ethanol were assessed. In photodynamic therapy applications, 655-nm laser light and chlorine e6 dissolved in ethanol were used. Using ethanol as an adjuvant therapy increased activity of Clorine e6 with quite low dose of light energy and photosensitizer concentration resulting in sufficient antibacterial effect. The energy dose of light and the concentration of the photosensitizer were reduced substantially so that healthy cells would not be damaged in in vivo or clinical studies.
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