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Abstract
Advances in combination medical treatment have offer new perspectives for acromegaly patients with persistent disease activity despite receiving the available medical monotherapies. The outcomes of combination medical treatment may reflect both additive and synergistic effects. This review focuses on combination medical treatment and its current position in acromegaly, based on clinical studies evaluating the efficacy and safety of combined medical treatment(s) and our own experiences with combination therapy. Arch Endocrinol Metab. 2019;63(6):646-52.
Highlights
Is a rare disorder predominantly caused by a growth hormone (GH)-secreting pituitary adenoma, resulting in elevated secretion of insulin-like growth factor-1 (IGF-1) [1]
This review aims to discuss the current position of combined medical treatment options in acromegaly
It is of importance to monitor medical therapies closely as it is crucial in controlling the disease
Summary
Is a rare disorder predominantly caused by a growth hormone (GH)-secreting pituitary adenoma, resulting in elevated secretion of insulin-like growth factor-1 (IGF-1) [1]. The vast majority of patients have macroadenomas, often with suprasellar extension In these cases, the postoperative remission rates are much lower [11]. In patients for whom surgery is contra-indicated, in whom prefer pharmacological treatment, or in whom postoperative remission is not achieved, additional treatment is needed. This is primarily in the form of medical treatment with radiotherapy generally reserved as a third-line treatment option [7,12]. Despite significant medical and surgical advances, many acromegaly patients are not adequately controlled For these patients advances in combination medical treatment offer new perspectives. The proposed position of combined medical treatment in acromegaly presented in this review are based on clinical studies evaluating the efficacy and safety of combined medical treatment(s) and our own experiences with combination therapy
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