The Polyploid State Plays a Tumor-Suppressive Role in the Liver

Abstract

(Developmental Cell 44, 447–459.e1–e5; February 26, 2018) In the originally published version of the article, the Declaration of Interests section did not include a financial interest and patent application. At the time of publication, H.Z. owned 90 shares of Alnylam stock worth approximately $9,000. Figures S3E and S3F were performed in collaboration with Alnylam. In addition, H.Z. and S.Z. hold a patent application entitled “Inhibitory RNA-Based Therapeutics Targeting ANLN for Cancer Treatment (International Patent Application No. PCT/US2017/034142 based on U.S. Serial No. 62/347,803).” The Declaration of Interests section has been updated here and in the article online. This correction does not affect the results in the article or the conclusions of this study. The authors regret this oversight. At the time of publication, H.Z. owned 90 shares of Alnylam Pharmaceuticals stock worth approximately $9,000. Figures S3E and S3F were performed in collaboration with Alnylam Pharmaceuticals. H.-C.T. and A.S. were employees of Alnylam Pharmaceuticals when the work was done. H.Z. and S.Z. hold a patent application entitled “Inhibitory RNA-Based Therapeutics Targeting ANLN for Cancer Treatment (International Patent Application No. PCT/US2017/034142 based on U.S. Serial No. 62/347,803).” The Polyploid State Plays a Tumor-Suppressive Role in the LiverZhang et al.Developmental CellFebruary 8, 2018In BriefMost liver cells are polyploid, but the functional role of wholesale genome duplications is unknown. To interrogate liver polyploidy function without irreversible manipulations of cell-cycle genes, Zhang et al. developed models to transiently alter ploidy, finding that polyploidy reduces tumor development by buffering against tumor-suppressor loss of heterozygosity. Full-Text PDF Open Archive