Abstract
Neutrophil movement is an important mechanism in the defense against injury or infection. This study examined the in vitro effect of human serum albumin (HSA), normal and heat inactivated foetal calf serum, and Bacteroides melaninogenicus sonicates on human neutrophils using a modified Boyden chamber. The results indicate that sonicates of B. melaninogenicus in the absence of serum or HSA are not either chemotactic or chemokinetic. On the other hand, HSA is chemokinetic, but the addition of B. melaninogenicus sonicates appeared to mask this effect. The results would suggest that the effect of HSA be at least standardized in assessing the presence or absence of in vitro PMN chemotactic anomalies to plaque organisms in relation to periodontal disease.
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