Abstract
Background: Interleukin-4 is best known as an important mediator and modular of immune and inflammatory responses to several diseases conditions such as hepatitis B, which is a significant health concern worldwide. Objectives: To estimate the frequency of different genotypes in IL 4 polymorphism gene -590 C/T in chronic Hepatitis B Virus patients and the control group. To correlate the different genotype of IL4 gene polymorphism with age, gender and location in Khartoum state. Method: IL4-590C/T polymorphism was examined in 56 patients with chronic hepatitis B and 30 non-hepatitis B infected controls, using the polymerase chain reaction –restriction length polymorphism method. Result: Our results showed a significant difference between the C/C, T/C, and T/T genotypes and the C and T alleles of the -590 region of IL-4 in chronic hepatitis B patients compared with the controls. Conclusion: Results of this study indicate that the functional gene polymorphisms of IL-4 may play an important part in the development of chronic hepatitis B.
Highlights
Hepatitis B virus (HBV) is a member of the Hepadnaviridae family of viruses, and has a double-stranded circular DNA and a DNA polymerase enzyme
Result: Our results showed a significant difference between the C/C, T/C, and T/T genotypes and the C and T alleles of the -590 region of IL-4 in chronic hepatitis B patients compared with the controls
Results of this study indicate that the functional gene polymorphisms of IL-4 may play an important part in the development of chronic hepatitis B
Summary
Hepatitis B virus (HBV) is a member of the Hepadnaviridae family of viruses, and has a double-stranded circular DNA and a DNA polymerase enzyme. It has two major proteins: hepatitis B surface antigen (HBs Ag), and hepatitis B core antigen, an inner protein. Hepatits B remains as one of the major causes of chronic hepatitis, liver cirrhosis, and hepatocellular carcinoma [4] HBV is present in blood and bodily secretions. The incubation period of HBV infection averages 75 days (range 1-6 months) [5]. The cellular and humoral immune responses to HBV infection are complex. Interleukin-4 is best known as an important mediator and modular of immune and inflammatory responses to several diseases conditions such as hepatitis B, which is a significant health concern worldwide
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