Abstract
Studies in adipose tissue gene expression and histology have focused largely on cross-sectional studies examining associations with measured metabolic parameters. These studies have contributed to our understanding of adipose tissue as a more active endocrine organ than previously envisioned. Yet, adipose tissue has the capacity to expand and contract more rapidly than other organs. Understanding the changes that occur with adipose tissue expansion/reduction may be crucial to preventing weight gain and aiding weight loss and maintenance. The study by Alligier et al. (1) in this issue of the JCEM examined early (at 14 d) and later (at 56 d) changes in whole adipose tissue gene expression and histology in individuals undergoing overfeeding. Not surprisingly, genes associated with lipid and fatty acid biosynthesis were increased early in overfeeding. The more compelling findings were those after 8 wk of overfeeding that demonstrated up-regulation of pathways involved in angiogenesis, extracellular matrix deposition, and the renin-angiotensin system (RAS) along with down-regulation of the cellular nutrient-sensing β-catenin-dependent Wnt pathway.
Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: The Journal of Clinical Endocrinology & Metabolism
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
