Abstract
Research in the area of developmental biology has historically focused on the key question of how different cell fates are determined in different regions of the body. From the point of view of producing a functioning organism, however, an equally important question is how cells acquire the appropriate polarities. Indeed, it is the polarisation of the single-cell embryo that underlies the diversification of cell fates that follows. One particular problem in this area is how groups of cells of the same or different fates coordinate their polarity with that of their neighbours and the axes of the tissue and organism as a whole.
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