The Placental Vascularization Indices Value and Placental Volume in Pregnancies with Antiphospholipid Syndrome for Pregnancy Outcome Prediction

Abstract

Background: The detection of antiphospholipid antibodies in the setting of arterial and venous thrombus and/or pregnancy loss involves antiphospholipid syndrome. APS may be primary in 40 % of instances where no proof of autoimmune disease is present, or secondary to autoimmune processes such as systemic erythematous lupus. Objectives: To explore the value of placental volume and placental vascularization indexes for predicting pregnancy results in pregnant women with antiphospholipid syndrome. Patient and Methods: One hundred pregnant women have been classified into 2 groups: Group A) group of controls (50 cases), (Group B) group of anti-phospholipids (50 cases). The perinatal results were associated with placental volume findings and indexes of placental vascularization. The precision in predicting the negative result was determined. Results: The indexes of placental vascularization, VI, FI and VFI in group B became lower in 1st and 2nd US scans with statistically significant P values (<0.05). Also placental volume was lower in antiphospholipid group in 1st and 2nd US scans with statistically significant P values (<0.001). A significant correlation was found among the two groups concerning the gestational age at termination of pregnancy, Apgar score and birth weight (with P-value < 0.05). Moreover, IUGR in group B was significantly associated with placental volume and placental vascularization indexes. Conclusion: In women who are pregnant with antiphospholipid syndrome, placental volume and placental vascularization indexes are good methods for evaluating fetal well-being and predicting neonatal outcomes.