Abstract
Optical coherence tomography (OCT) is an increasingly used new method that investigates changes in the retinal nerve fiber layer (RNFL) in neurodegenerative diseases. It provides high-resolution cross-sectional imaging of biological tissues. This study aimed to investigate the structural changes in RNFL in patients with obsessive compulsive disorder (OCD) using OCT and to investigate the possible effects of retinal function on the etiopathogenesis of OCD. In this study, 30 patients diagnosed with OCD at the end of the Structured Clinical Interview for DSM (SCID-I), without any drug use status, and 31 healthy participants paired with the patients in terms of their sociodemographic characteristics were included. In the patient and control groups, the RNFL thickness was measured and compared at each locus using OCT. Statistically significant differences were found in RNFL, ganglion cell layer thickness, and central foveal thickness between the patients with OCD and the control group. In this study, the choroidal thickness values of the patient group were found to be higher than those of the control group; and a statistically significant difference was observed in the mean choroidal thickness values (p=0.045). The findings of the study suggest that the RNFL thickness of patients with OCD does not decrease, but choroidal thickness may be an important biomarker to determine the etiopathogenesis of the disease and follow neurodegeneration.
Highlights
Obsessive compulsive disorder (OCD) is a psychiatric disorder that has a place in daily life
Materials and Methods: In this study, patients diagnosed with OCD at the end of the Structured Clinical Interview for DSM (SCID-I), without any drug use status, and healthy participants paired with the patients in terms of their sociodemographic characteristics were included
Statistically significant differences were found in retinal nerve fiber layer (RNFL), ganglion cell layer thickness, and central foveal thickness between the patients with OCD and the control group
Summary
Obsessive compulsive disorder (OCD) is a psychiatric disorder that has a place in daily life It disrupts functionality and affects occupational and social skills. The anxiety caused by thoughts results in the counterattack of practicing certain habits (compulsions) against the troublesome obsession This attack provides a temporary sense of relief; it can take away hours from the person’s lifecycle as it becomes a ritual. No noteworthy or comprehensive results have been announced from the previous research on the relationship between OCD and genetics, it would be out of the question to claim no relationship between the aforementioned concepts Another prominent method in the light of recent developments is to investigate the relationship between any deformation and psychiatric disorders using imaging techniques [2,3,4]. The same cycle of OCD important in pathophysiology [9]
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