Abstract
Small non‐coding RNAs have been recognized as key players in gene regulation. In 2006, we and others discovered a novel class of small RNAs that interact with Piwi proteins in the germline of diverse organisms. These Piwi‐interacting RNAs (piRNAs), mostly 26–32 nucleotide in length and correspond to all types of genomic sequences, represent a distinct small‐RNA pathway. In my talk, I will report our recent progress that reveal the crucial roles of the Piwi‐piRNA pathway in mediating the regulation of mRNA and lncRNA stability by transposons and pseudogenes, which represent a new paradigm of regulation among the major constituents of the genome.Support or Funding InformationThis work was supported by the NIH grant R37HD42012 and a Mathers Foundation award.
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