Abstract
Background: Signal Transducer and Activator of Transcription 3 (STAT3) is an intracellular signaling molecule which, in trophoblastic cells, can be phosphorylated at its tyr705 (p-STAT3 tyr705) residue by Leukemia Inhibitory Factor (LIF) receptor binding. This phosphorylation correlates with invasiveness. Protein inhibitors of activated STATs (PIAS) antagonize STAT function by interfering with STAT DNA-binding and are, therefore, expected to regulate trophoblast invasion.
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