Abstract
Tetrastigma hemsleyanum Diels & Gilg (TDG), the family member of Vitaceae, is a traditional herbal medicine in China. The root of TDG can be immediately used after cleaning the muddy soil, and can be dehydrated for dry use. TDG is able to be collected all year round, which is commonly used in the treatment of hepatitis, infantile high fever, snake bite, etc. Based on phytochemistry, the chemical components of TDG are divided into flavonoids, phenolic acids, terpenes, steroids, polysaccharide, and other compounds, showing many pharmacological effects which include anti-tumor, anti-oxidation, anti-inflammatory, antipyretic, analgesic, and immunomodulatory activity, as well as other activities. Currently, TDG involves some problems of the reduction of wild resources, the backward processing methods, and storage difficulties as well as the imperfection of detection methods. Therefore, this review summarizes the literature of the past 20 years, and the purpose of this review is to summarize the recent researches on the phytochemistry, pharmacology, quality control, and clinical application of TDG. The above discussions provide new insights for the future research on TDG.
Highlights
Tetrastigma hemsleyanum Diels & Gilg is a perennial Liana plant of family Vitaceae
The results prove that ethyl triacetate fraction (EAF) isolated from Tetrastigma hemsleyanum Diels & Gilg (TDG) is able to increase the mouse spleen lymphocyte transformation induced by concanavalin A (ConA), the delayed type hypersensitivity (DTH) in dose-dependent manner, as well as significantly enhancing the ability of macrophages to phagocytose India ink
This review summarizes the knowledge of TDG in phytochemistry, pharmacology, quality control, and clinical application in recent years
Summary
Tetrastigma hemsleyanum Diels & Gilg (abbreviated as TDG) is a perennial Liana plant of family Vitaceae. TDG is widely used as a traditional medicine with its root being used after washing or processing (Zhejiang Food and Drug Administration, 2015; Ding F. et al, 2018; Ding Z. et al, 2018). It is mainly distributed in the south regions along the Yangtze River, such as Zhejiang province, Fujian province, Guangxi province, and so on. The tuberous roots or whole grass of TDG can be commonly used as medicine, with the effect of clearing away heat and detoxification, eliminating swelling and pain, promoting blood circulation and removing blood stasis, dispelling wind and phlegm.
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