Abstract
During the follicular phase of the primate menstrual cycle, a single follicle usually matures to the preovulatory stage and releases its oocyte for fertilization and the potential establishment of pregnancy. In assisted reproductive technology procedures, it is desirable to override the natural process of follicle selection to produce many oocytes that are capable of being fertilized and undergoing normal embryo development. The goal of this chapter is to summarize the current views regarding the natural process of follicle selection in primates and to discuss how this process may be amplified to produce a greater number of oocytes.
Highlights
The goal of this review is to summarize the current views regarding the regulation of the primate menstrual cycle with particular reference to the physiological mechanisms involved in the selection of a single preovulatory follicle and to discuss the mechanisms by which this process may be overridden to achieve the production of multiple preovulatory follicles to obtain more oocytes for use in assisted reproductive technology studies
Granulosa cell division continues and the number of granulosa cell layers increase as the preantral follicle grows
It is generally accepted that the stages of follicular development up to and including the early antral follicle are relatively independent ofthe pituitary gonadotropins, follicle stimulating hormone (FSH) and luteinizing hormone (LH)
Summary
Dynamics of human follicular growth: morphologic,, dynamic and functional aspects. 5. Zeleznik AJ, Wildt L, Schuler HM: Characterization of ovarian folliculogenesis during the luteal phase of the menstrual cycle in rhesus monkeys using [3H] thymidine autoradiography. 6. Peters H, Byskov AG, Grinsted J: Follicular growth in fetal and prepubertal ovaries of humans and other primates. 7. Zeleznik AJ, Midgley AR Jr, Reichert LE Jr: Granulosa cell matauration in the rat: increased binding of human chorionic gonadotropin following treatment with follicle stimulating hormone in vivo. 8. Zeleznik AJ, Schuler HM, Reichert LE Jr: Gonadotropin-binding sites in the rhesus monkey ovary: role of the vasculature in the selective distribution of human chorionic gonadotropin to the preovulatory follicle.
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
