Abstract
Extracts of locust corpora cardiaca accelerate heart beat, increase amaranth excretion through the Malpighian tubules, and increase the active phosphorylase levels in the fat body. Locust corpora cardiaca are also effective in elevating the haemolymph sugars in Periplaneta. Two biologically active fractions are obtained by the chromatography of whole glands and the separated storage and glandular lobes. When animals are injected with 35S cysteine 4 hr prior to the removal of their corpora cardiaca, these fractions contain less than 2% of the total 35S label in the whole corpora cardiaca. The two fractions are thought to contain biologically active peptides. The two biologically active fractions may be distinguished by their different effects in the four assay systems described. The slower moving fraction is active only in glandular lobe and whole gland extracts. It is most potent in accelerating the heart beat and elevating the active phosphorylase in the fat body. The faster moving of the two factors is active only in storage lobe and whole gland extracts. It is most potent in stimulating the excretion of amaranth through the Malpighian tubules. The possible origins and nature of the two factors are discussed.
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