Abstract
The anhydrosugar, glucosane (C6H10O5), and its polymer, tetra-glucosane, are widely used in Germany in the dietary treatment of diabetes. These substances are reputed to be oxidized by the diabetic since, according to Nothmann and Kuhnau1 and others, no extra urinary sugar results after its administration, no rise in blood sugar occurs thereafter, and an antiketogenic and protein sparing action follows its ingestion. It is likewise claimed to be glycogenic.In the present paper we have investigated the behavior of “Salabrose,” a commercial tetra-glucosane preparation obtained from Germany, and have administered it orally, subcutaneously, and intraperitoneally to normal and phlorhizinized dogs. In order to determine whether glucosane might be excreted unchanged in the urine or feces following its administration, it has been quantitatively determined by reconversion to glucose by boiling for a short interval with dilute mineral acid. It was found that boiling for 15 minutes with 20 or 30 per cent HC1 destroy...
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